Maleic hydrazide
3,6-Dihydroxypyridazine
CAS: 123-33-1
Molecular Formula: C4H4N2O2
Maleic hydrazide - Names and Identifiers
Maleic hydrazide - Physico-chemical Properties
| Molecular Formula | C4H4N2O2 |
| Molar Mass | 112.09 |
| Density | 1,6 g/cm3 |
| Melting Point | 299-301°C (dec.)(lit.) |
| Boling Point | 209.98°C (rough estimate) |
| Flash Point | 300°C |
| Water Solubility | 6 g/L |
| Solubility | 4510mg/l |
| Vapor Presure | 0.289mmHg at 25°C |
| Appearance | White lens |
| Color | White crystalline |
| Odor | Odorless |
| Merck | 14,5705 |
| BRN | 112223 |
| pKa | 9.01±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.4610 (estimate) |
| MDL | MFCD00006665 |
| Physical and Chemical Properties | Melting point 306-308°C water-soluble 6g/L |
| Use | Used as pesticide, pharmaceutical intermediates |
Maleic hydrazide - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect R68 - Possible risk of irreversible effects |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 2 |
| RTECS | UR5950000 |
| TSCA | Yes |
| HS Code | 29339990 |
| Toxicity | LD50 orally in rats: 3800-6800 mg/kg; dermally in rabbits: >4000 mg/kg (Ben-Dyke) |
Maleic hydrazide - Upstream Downstream Industry
| Raw Materials | Hydrazine sulfate Hydrazine sulfate hydrazine hydrate hydrazine hydrate Maleic anhydride Maleic anhydride |
| Downstream Products | 3,6-Dichloropyridazine |
Maleic hydrazide - Introduction
The solubility in water at 25 ℃ is about 0-6%, in ethanol is 0-1%, and in dimethylformamide is 2-4%. Its sodium, potassium and ammonium salts and organic phosphorus salts are easily soluble in water.
Last Update：2022-10-16 17:12:52
Maleic hydrazide - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 3 (Vol. 4, Sup 7) 1987 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| toxicity | acute oral LD501400mg/kg in rats, its sodium salt is 6950 mg/kg, diethanol salt is 2340 mg/kg. No stimulation. Rats fed with feed containing 5% of the original drug for 2 years did not appear poisoning symptoms, no teratogenic, carcinogenic, mutagenicity. Low toxicity to fish, bass LC5075mg/L. Non-toxic to bees. |
| use | plant growth regulator. Through leaf surface or root inhalation, it is conducted by xylem and phloem, inhibiting cell division and inhibiting plant growth. 0.1% ~ 0.05% liquid medicine can control grasses, lawns, orchards and waterside weeds. 0.025% liquid medicine inhibits germination of onions and potatoes during storage. 0.1% ~ 0.05% liquid medicine inhibits and delays the growth of tobacco lateral buds and keeps citrus seedlings from frost damage. Used as a plant growth inhibitor Used as a pesticide and pharmaceutical intermediate maleic hydrazide is a selective herbicide and a temporary plant growth inhibitor. The agent can enter the plant through the leaf stratum corneum, reduce photosynthesis, osmotic pressure and evaporation, and can strongly inhibit the growth of buds. It is used to prevent potatoes, onions, garlic and radishes from germinating during storage, and has the effect of inhibiting crop growth and prolonging flowering. It can also be used for weeding non-cultivated land. The tautomerism of this product is 3, 6-dihydroxypyridazine (3,6-Dihydroxypyridazine). It is an intermediate of sulfamethoxazine. Biochemical research Maleic hydrazide is a selective herbicide and temporary plant growth inhibitor. |
| Production method | It is obtained by the reaction of maleic anhydride and hydrazine hydrate. Water and 40% hydrazine hydrate are added into the reaction pot, 30% hydrochloric acid is added dropwise under stirring and cooling, the temperature is controlled below 20 ℃ until the pH value is 6.2-6.4, maleic anhydride is added, the temperature is slowly raised to 106-110 ℃, the temperature is refluxed for 2 hours, the temperature is lowered to 5 ℃, the filter is filtered, the filter cake is washed with ice water to pH4.8-5.1, and dried to obtain maleic hydrazide with 97% yield. It is prepared by the reaction of butadiene anhydride (or butadiene diacid) and hydrazine sulfate at 35~56 ℃. |
| category | pesticide |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 3000 mg/kg |
| flammability hazard characteristics | combustion produces toxic nitrogen oxide gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | dry powder, foam, sand |
| auto-ignition temperature | 707 °F |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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View History
Raw Materials for Maleic hydrazide
Hydrazine sulfate
Hydrazine sulfate
hydrazine hydrate
hydrazine hydrate
Maleic anhydride
Maleic anhydride
Hydrazine sulfate
hydrazine hydrate
hydrazine hydrate
Maleic anhydride
Maleic anhydride
Downstream Products for Maleic hydrazide